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KMID : 0366220130480010063
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Korean Journal of Hematology
2013 Volume.48 No. 1 p.63 ~ p.66
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Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor
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Kang Keun-Hee
Park Joo-Hee
Ryu Ja-Young
Lee Sang-Yup
Ko Gang-Jee
Kwon Young-Joo
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Abstract
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Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8×109/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient’s condition rapidly deteriorated and the patient died on day 23 of hospital stay. Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis.
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KEYWORD
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G-CSF, Anaplastic thyroid carcinoma, Paraneoplastic leukocytosis
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